Description
Product Characteristics:
Plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Required to sustain and/or integrate signals required for proper lineage commitment and maturation of T-cells. Regulates T-cell development through T-cell antigen receptor (TCR) signaling and in particular through the regulation of calcium influx and phosphorylation of Erk (By similarity).
Subcellular location: Cytoplasm, Nucleus
Synonyms: GASP, SPOT, TSEPA, C6orf190, C6orf207, bA325O24.3, bA325O24.4, Protein THEMIS, Thymocyte-expressed molecule involved in selection, THEMIS
Target Information: This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]